How long can one enjoy a flat, tasteless life devoid of meaning? Maybe you can do without one of them -- meaning or flavor -- but not both.
Where does meaning come from? What connects signifier to signified?
Not the connection but the process that makes it -- awareness, consciousness -- that who is, what is, all that is.
Where does that process come from? Is it created by the brain or does it contain the brain? A moebius strip -- locally two sided, globally one sided.
Is it enough? Enough, not enough, all a judgement. Make the judgements happy. Be at peace. Or not. What else can you do?